In Vivo and In Vitro Study of the Genetic Effects of Cabergoline Drug

This study aimed to stand on genetic effects important of cabergoline drug. toxic effect was evaluated for three different doses (0.05, 0.1, 0.5 mg/ml) in comparison with control (PBS/ phosphate buffer saline) both vivo and vitro. In involved the cytogenetic evaluation mice by examination mitotic index percentage (MI), micronucleus formation (MN) chromosomal aberrations. Result indicated that all tested cause significant reduction MI percentage, while rise seen MN studied While vitro measuring normal cell line (REF/ Rat embryonic fibroblast) studing viability through MTT assay a TP53 codon 72 polymorphism (rs1042522) (PCR-RFLP). Results recorded caused high proliferation cells at p53 showed Arg allele yielding two fragments 213 140 bp after cleaving BstuI,, Pro had single 353 band because it did not cleaved BstuI. conclusion according results care should be taken obtaining as its side effects.